GKN1 Gene Summary [Human]
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GKN1 |
| Official Name | gastrokine 1 [Source:HGNC Symbol;Acc:HGNC:23217] |
| Ensembl ID | ENSG00000169605 |
| Bio databases IDs | |
| Aliases | gastrokine 1, BRICHOS domain containing 1 |
| Synonyms | 2200002K21RIK, AMP-18, BRICD1, CA11, FOV, foveolin, gastrokine 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GKN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BRICHOS domain
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GKN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- signal transduction
- positive regulation of cell proliferation
- digestion
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding