PYDC1 Gene Summary [Human]
Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including negative regulation of tumor necrosis factor-mediated signaling pathway; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytosol and nucleus. Part of IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PYDC1 |
| Official Name | pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30261] |
| Ensembl ID | ENSG00000169900 |
| Bio databases IDs | |
| Aliases | pyrin domain containing 1 |
| Synonyms | ASC2, ASCL, ASC-like, cPOP1, POP1, PYC1, pyrin domain containing 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PYDC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAAD/DAPIN/Pyrin domain
- protein serine/threonine kinase inhibitor
- protein kinase binding
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PYDC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of tumor necrosis factor-mediated signaling pathway
- innate immune response
- negative regulation of interleukin-1 beta production
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of interleukin-1-mediated signaling pathway
- negative regulation of NLRP3 inflammasome complex assembly
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- IkappaB kinase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase inhibitor activity
- protein binding