CDK5R2 Gene Summary [Human]
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDK5R2 |
| Official Name | cyclin dependent kinase 5 regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:1776] |
| Ensembl ID | ENSG00000171450 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 5 regulatory subunit 2, neuronal CDK5 activator isoform |
| Synonyms | B230310J22Rik, cyclin dependent kinase 5, regulatory subunit 2, cyclin-dependent kinase 5 regulatory subunit 2, NCK5AI, P39, p39nck5ai, RGD1562530 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK5R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- cytoskeletal protein binding
- actin binding
- Cdk5 binding domain
- cyclin-dependent protein kinase regulator
- Cyclin-dependent kinase 5 activator protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chromatolysis
- seizures
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- systemic lupus erythematosus
role in cell
- migration
- phosphorylation in
- differentiation
- formation
- formation in
- cell viability
- morphology
- growth
- outgrowth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- high-density microsomal fractions
- detergent-insoluble fractions
- cytoplasmic cytoskeleton
- Cytoplasm
- presynaptic regions
- cell periphery
- cellular membrane
- actin cytoskeleton
- cell cortex
- Plasma Membrane
- cytoplasmic particles
- membrane ruffles
- plasma membrane projections
- insulin secretory granules
- growth cone
- neurites
- actin stress fibers
- filopodia
- perikaryon
- axons
- dendrites
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK5R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- layer formation in cerebral cortex
- cerebellum development
- axon guidance
- superior olivary nucleus maturation
- hippocampus development
- brain development
- positive regulation of calcium ion-dependent exocytosis
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- membrane
- neuron projection
- cyclin-dependent protein kinase 5 holoenzyme complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- actin binding
- lipid binding