CDK5

CDK5 Gene Summary

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Details

Type
Protein Coding
Official Symbol
CDK5
Official Name
cyclin dependent kinase 5 [Source:HGNC Symbol;Acc:HGNC:1774]
Ensembl ID
ENSG00000164885
Bio databases IDs NCBI: 1020 Ensembl: ENSG00000164885
Aliases cyclin dependent kinase 5
Synonyms
Crk6,cyclin-dependent kinase 5,LIS7,Neuronal cdc2-like kinase,PSSALRE
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cyclin-dependent protein kinase
  • protein serine/threonine kinase
  • acetylcholine receptor agonist
  • Protein kinase (unclassified specificity)
  • protein kinase
  • protein kinase binding
  • ATP-binding domain
  • Protein tyrosine and serine/threonine kinase
  • heat shock protein binding
  • ephrin receptor binding
  • enzyme
  • p53 binding
  • protein binding
  • receptor binding
  • Protein kinase domain
  • phosphorylation site
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • kinase domain
  • cytoskeletal protein binding
  • Protein Kinases, catalytic domain
  • alcohol group acceptor phosphotransferase
  • Neu/ErbB-2 receptor binding
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • HTR6
  • AR
  • Spdye4a
  • KCTD13
  • SPDYE1
  • AGAP2
  • NES
  • AATK
  • PRKN
  • RHOG
disease
  • tauopathy
  • Huntington disease
  • neurodegeneration
  • Alzheimer disease
  • neoplasia
  • cancer
  • COVID-19
  • seizures
  • cognitive impairment
  • metastasis
regulated by
  • D-glucose
  • RELN
  • MAPT
  • APP
  • TGFB1
  • beta-estradiol
  • oxaliplatin
  • ASCL1
  • SOD1
  • TNF
regulates
  • GSK3B
  • AR
  • AKT
  • MTOR
  • CDK2
  • Ca2+
  • AKT1
  • JUN
  • insulin
  • CDKN1B
role in cell
  • dephosphorylation in
  • expression in
  • proliferation
  • accumulation in
  • activation
  • differentiation
  • phosphorylation in
  • density
  • binding
  • quantity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • microtubule fractions
  • synaptic plasma membrane fractions
  • nuclear fraction
  • soluble fraction
  • detergent-insoluble fractions
  • membrane fraction
  • cytoplasmic cytoskeleton
  • glutaminergic synapse
  • cell junction
  • Cytoplasm
  • presynaptic regions
  • cell periphery
  • perinuclear region
  • postsynaptic region
  • cellular membrane
  • focal adhesions
  • actin cytoskeleton
  • Plasma Membrane
  • microtubules
  • intermediate filaments
  • cytosol
  • membrane ruffles
  • nucleoplasm
  • sperm tail
  • outer dense fibers
  • dendritic spines
  • neuromuscular junctions
  • growth cone
  • neurites
  • synapse
  • filopodia
  • perikaryon
  • axons
  • dendrites
  • postsynaptic density
  • dendritic shafts
  • lamellipodia
  • microspikes
  • detergent-soluble fraction
  • vesicle fraction
  • cytoskeletal fraction
  • synaptosomal fractions
  • cytoplasmic fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CDK5 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • visual learning
  • central nervous system neuron development
  • intracellular protein transport
  • receptor catabolic process
  • negative regulation of transcription, DNA-dependent
  • synaptic vesicle transport
  • synaptic vesicle endocytosis
  • negative regulation of synaptic plasticity
  • axonogenesis
  • regulation of synaptic plasticity
  • regulation of cell cycle
  • negative regulation of protein ubiquitination
  • regulation of synaptic transmission, glutamatergic
  • neuron apoptotic process
  • regulation of dendritic spine morphogenesis
  • regulation of excitatory postsynaptic membrane potential
  • negative regulation of protein export from nucleus
  • neuron differentiation
  • synaptic transmission
  • regulation of apoptotic process
  • receptor clustering
  • microtubule cytoskeleton organization
  • corpus callosum development
  • synapse assembly
  • regulation of macroautophagy
  • sensory perception of pain
  • regulation of cell migration
  • peptidyl-serine phosphorylation
  • peptidyl-threonine phosphorylation
  • calcium ion import
  • layer formation in cerebral cortex
  • positive regulation of protein targeting to membrane
  • motor axon guidance
  • Schwann cell development
  • negative regulation of cell cycle
  • negative regulation of proteolysis
  • protein phosphorylation
  • positive regulation of neuron apoptotic process
  • cerebellar cortex formation
  • dendrite morphogenesis
  • cell division
  • neuron migration
  • synaptic transmission, dopaminergic
  • behavioral response to cocaine
  • phosphorylation
  • protein localization to synapse
  • synaptic vesicle exocytosis
  • cell-matrix adhesion
  • oligodendrocyte differentiation
  • neuron projection development
  • hippocampus development
  • positive regulation of calcium ion-dependent exocytosis
  • rhythmic process
  • axon extension
  • negative regulation of axon extension
  • skeletal muscle tissue development
  • synaptic transmission, glutamatergic

CELLULAR COMPONENT

Where in the cell the gene product is active
  • postsynaptic density
  • cyclin-dependent protein kinase holoenzyme complex
  • neuronal cell body
  • perikaryon
  • neuron projection
  • plasma membrane
  • nucleoplasm
  • microtubule
  • growth cone
  • nucleus
  • dendrite
  • cytoplasm
  • membrane
  • cytosol
  • cell junction
  • filopodium
  • neuromuscular junction
  • cyclin-dependent protein kinase 5 holoenzyme complex
  • axon
  • lamellipodium

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • ErbB-2 class receptor binding
  • protein kinase activity
  • ErbB-3 class receptor binding
  • cyclin-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • microtubule binding
  • tau-protein kinase activity
  • ATP binding
  • acetylcholine receptor activator activity
  • p53 binding
  • protein binding
  • tau protein binding
  • Hsp90 protein binding
  • kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.