FRMD5 Gene Summary [Human]
Enables integrin binding activity and protein kinase binding activity. Involved in negative regulation of cell motility; positive regulation of cell adhesion; and regulation of cell migration. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FRMD5 |
| Official Name | FERM domain containing 5 [Source:HGNC Symbol;Acc:HGNC:28214] |
| Ensembl ID | ENSG00000171877 |
| Bio databases IDs | |
| Aliases | FERM domain containing 5 |
| Synonyms | 1500032A09RIK, A930004K21Rik, FERM domain containing 5, MGC14161, NEDEMA, RGD1561554 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRMD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM adjacent (FA)
- FERM central domain
- Band 4.1 homologues
- protein kinase binding
- Ubl1_cv_Nsp3_N-like
- integrin binding
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- FERM N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRMD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- negative regulation of cell motility
- positive regulation of cell adhesion
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- integrin binding
- cytoskeletal protein binding