Frmd5 Gene Summary [Rat]
Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actomyosin structure organization; negative regulation of cell motility; and positive regulation of cell adhesion. Predicted to be located in adherens junction. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frmd5 |
| Official Name | FERM domain containing 5 [Source:RGD Symbol;Acc:1561554] |
| Ensembl ID | ENSRNOG00000016189 |
| Bio databases IDs | |
| Aliases | FERM domain containing 5 |
| Synonyms | 1500032A09RIK, A930004K21Rik, FERM domain containing 5, MGC14161, NEDEMA, RGD1561554 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Frmd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM adjacent (FA)
- FERM central domain
- Band 4.1 homologues
- protein kinase binding
- Ubl1_cv_Nsp3_N-like
- integrin binding
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- FERM N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Frmd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- negative regulation of cell motility
- positive regulation of cell adhesion
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- integrin binding
- cytoskeletal protein binding