NME6 Gene Summary [Human]
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | NME6 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 6 [Source:HGNC Symbol;Acc:HGNC:20567] |
| Ensembl ID | ENSG00000172113 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 6 |
| Synonyms | IPIA-ALPHA, IPIA-α, NDK 6, NM23-H6, nm23-M6, Nm23-R6, NME/NM23 nucleoside diphosphate kinase 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NME6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- Nucleoside diphosphate kinase family
- NDPk
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NME6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- UTP biosynthetic process
- negative regulation of cell growth
- CTP biosynthetic process
- GTP biosynthetic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- nucleoside diphosphate kinase activity