NOCT Gene Summary [Human]

The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
NOCT
Official Name
nocturnin [Source:HGNC Symbol;Acc:HGNC:14254]
Ensembl ID
ENSG00000151014
Bio databases IDs NCBI: 25819 Ensembl: ENSG00000151014
Aliases nocturnin
Synonyms Ccr4, CCR4C, CCR4L, CCRN4L, Ccrn4lb, NOC, nocturnin
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOCT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • poly(A)-specific ribonuclease
  • mRNA binding
  • NADP phosphatase
  • Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  • phosphatase
  • Endonuclease/Exonuclease/phosphatase family
  • protein binding

Pathways

Biological processes and signaling networks where the NOCT gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obesity
regulated by
regulates
  • PPARG
  • IGF1
  • lipid
  • D-glucose
  • NADPH
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II
  • RORB
  • FRRS1L
role in cell
  • differentiation
  • expression in
  • assembly
  • G1 phase

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cytoplasmic mRNA processing body
  • Cytoplasm
  • perinuclear region
  • Mitochondria
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NOCT gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of embryonic development
  • transcription from RNA polymerase II promoter
  • positive regulation of fat cell differentiation
  • regulation of circadian rhythm
  • negative regulation of osteoblast differentiation
  • negative regulation of gene expression
  • circadian regulation of gene expression
  • mRNA stabilization
  • NADP metabolic process
  • cytoplasmic mRNA processing body assembly
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • response to lipopolysaccharide

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • perinuclear region of cytoplasm
  • cytoplasm
  • mitochondrion
  • cytoplasmic mRNA processing body
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • poly(A)-specific ribonuclease activity
  • 3'-5'-exoribonuclease activity
  • metal ion binding
  • mRNA binding
  • NADP phosphatase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.