CDC7
CDC7 Gene Summary
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC7 |
| Official Name | cell division cycle 7 [Source:HGNC Symbol;Acc:HGNC:1745] |
| Ensembl ID | ENSG00000097046 |
| Bio databases IDs | |
| Aliases | cell division cycle 7 |
| Synonyms | CDC7L1,CDC7-RELATED KINASE,cell division cycle 7,HsCDC7,Hsk1,huCDC7,muCdc7 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- DAM-2 motif
- protein kinase
- Protein Kinases, catalytic domain
- ATP-binding domain
- nuclear retention sequence
- protein binding
- DAM-1 motif
Pathways
Biological processes and signaling networks where the CDC7 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AR
- CDKN2A
- PLOD1
- DBF4
- TRIM27
- EGLN3
- XPO1
- ZBTB26
- KCNA3
- RBFOX3
disease
- invasive breast cancer
- organismal death
- liver cancer
- epithelial cancer
- preeclampsia
- lung squamous cell carcinoma
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- uterine leiomyoma
regulated by
- fibroblasts
- hydroxyurea
- TP53
- ERBB2
- lipopolysaccharide
- TFEB
- L3MBTL2
- KRAS
- PLK1
- CDC7
regulates
- p38 MAPK
- CASP9
- TP53
- CLSPN
- MCM2
- CASP8
- DBF4
- MCM
- CHEK1
- RAD51
role in cell
- phosphorylation in
- binding in
- activation in
- apoptosis
- growth
- cell death
- binding
- cell viability
- proliferation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasmic fraction
- chromatin fraction
- Cytoplasm
- cytoplasmic bridges
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CDC7 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell division
- positive regulation of DNA replication involved in S phase
- double-strand break repair via break-induced replication
- signal transduction
- G1/S transition of mitotic cell cycle
- positive regulation of cell proliferation
- peptidyl-serine phosphorylation
- positive regulation of G2/M transition of mitotic cell cycle
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- mitotic spindle
- cytoplasm
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity