NEGR1 Gene Summary [Human]
Predicted to act upstream of or within several processes, including feeding behavior; locomotory behavior; and positive regulation of neuron projection development. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NEGR1 |
| Official Name | neuronal growth regulator 1 [Source:HGNC Symbol;Acc:HGNC:17302] |
| Ensembl ID | ENSG00000172260 |
| Bio databases IDs | |
| Aliases | neuronal growth regulator 1, a kindred of IgLON, neurotractin, IgLON family member 4 |
| Synonyms | 5330422G01Rik, DMML2433, IGLON4, KILON, neuronal growth regulator 1, Ntra |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEGR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- ion channel binding
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- neoplasia
- Alzheimer disease
- COVID-19
- systemic lupus erythematosus
- major depression
- insomnia
- schizophrenia
- obesity
- neuroblastoma
role in cell
- expression in
- differentiation
- activation in
- proliferation
- growth
- formation
- development
- morphogenesis
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Extracellular Space
- outer leaflet
- dendritic spines
- late endosomes
- perikaryon
- dendrites
- postsynaptic density
- dendritic shafts
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEGR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- neuron projection development
- feeding behavior
- positive regulation of neuron projection development
- regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuronal cell body
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding