KIF23 Gene Summary [Human]
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | KIF23 |
| Official Name | kinesin family member 23 [Source:HGNC Symbol;Acc:HGNC:6392] |
| Ensembl ID | ENSG00000137807 |
| Bio databases IDs | |
| Aliases | kinesin family member 23 |
| Synonyms | 3110001D19Rik, C87313, CDA3, CDAIII, CDAN3, CDAN3A, CHO1, kinesin family member 23, Kinesin-like 5, KNSL5, MKLP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- Arf6-interacting domain of mitotic kinesin-like protein 1
- tail domain
- protein binding
- microtubule motor protein
- phosphorylation site
Pathways
Biological processes and signaling networks where the KIF23 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- invasive breast cancer
- nonalcoholic fatty liver disease
- metastasis
- endometrial adenocarcinoma formation
- breast carcinoma
- invasive breast carcinoma
- organismal death
- congenital dyserythropoietic anemia type IIIa
role in cell
- expression in
- proliferation
- growth
- accumulation in
- migration
- growth in
- epithelial-mesenchymal transition
- quantity
- formation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- midbody center
- mitotic structure
- spindle apparatus
- Nucleus
- centrosome
- Mitochondria
- microtubules
- midbody
- Flemming body
- cytoplasmic bridges
- cytosol
- nucleoplasm
- membrane processes
- central spindle
- mitotic spindle
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle elongation
- spindle midzone assembly involved in mitosis
- cytokinesis after mitosis
- microtubule-based movement
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- focal adhesion
- mitotic spindle
- centralspindlin complex
- spindle
- cytosol
- kinesin complex
- midbody
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding