MAOA
MAOA Gene Summary
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAOA |
| Official Name | monoamine oxidase A [Source:HGNC Symbol;Acc:HGNC:6833] |
| Ensembl ID | ENSG00000189221 |
| Bio databases IDs | |
| Aliases | monoamine oxidase A |
| Synonyms | 1110061B18Rik,BRNRS,Mao,Monoamine Oxidase A,monoamine oxidase type A,NC61C12.R1,type A monoamine oxidase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- amine oxidase (flavin-containing)
- flavin adenine dinucleotide binding
- amine oxidase
- serotonin binding
- NAD(P)-binding Rossmann-like domain
- enzyme
- protein binding
- Flavin containing amine oxidoreductase
- CH-NH2 group:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the MAOA gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MTCH2
- CUL3
- RPA2
- PRKN
- UBC
- MHC II (complex)
- HNRNPL
- MAPT
- moclobemide
- isocarboxazid
disease
- epithelial neoplasia
- neoplasia
- epithelial cancer
- cancer
- ventricular fibrillation
- non-endogenous depressive disorder
- conduct disorder
- ventricular arrhythmia
- Alzheimer disease
- ventricular tachycardia
regulated by
- lipopolysaccharide
- carnosine
- resveratrol
- dihydrotestosterone
- procainamide
- progesterone
- MAPK14
- iproniazid
- dexamethasone
- AR
regulates
- reactive oxygen species
- BCL2
- adenosine triphosphate
- CASP3
- MCL1
- ALB
- VIM
- CD44
- MYC
- CCL2
role in cell
- expression in
- migration
- number
- binding in
- apoptosis
- cell death
- accumulation in
- activation in
- invasion by
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- cytosol
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAOA gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- dopamine catabolic process
- positive regulation of signal transduction
- cellular biogenic amine metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial outer membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- aliphatic-amine oxidase activity
- flavin adenine dinucleotide binding
- primary amine oxidase activity