NTM Gene Summary [Human]
This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | NTM |
| Official Name | neurotrimin [Source:HGNC Symbol;Acc:HGNC:17941] |
| Ensembl ID | ENSG00000182667 |
| Bio databases IDs | |
| Aliases | neurotrimin, IgLON family member 2 |
| Synonyms | 6230410L23RIK, B230210G24RIK, CEPU-1, GP65, HNT, Igdcc2, IGLON2, neurotrimin, NTRI, RNU16845 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- COVID-19
- metabolic syndrome X
- insomnia
- schizophrenia
- prostate cancer
- sunburn
- non-Hodgkin disease
- idiopathic pulmonary fibrosis
- colorectal cancer
role in cell
- proliferation
- migration by
- development
- recognition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- perinuclear region
- presynaptic membrane
- synaptic membrane
- synapse
- axons
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron recognition
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding