NLRP13 Gene Summary [Human]
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | NLRP13 |
| Official Name | NLR family pyrin domain containing 13 [Source:HGNC Symbol;Acc:HGNC:22937] |
| Ensembl ID | ENSG00000173572 |
| Bio databases IDs | |
| Aliases | NLR family pyrin domain containing 13, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13 |
| Synonyms | CLR19.7, NALP13, NLR family pyrin domain containing 13, NOD14, PAN13 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLRP13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat, ribonuclease inhibitor type
- Leucine rich repeat
- NACHT domain
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the NLRP13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLRP13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding