ANGEL2 Gene Summary [Human]
Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ANGEL2 |
| Official Name | angel homolog 2 [Source:HGNC Symbol;Acc:HGNC:30534] |
| Ensembl ID | ENSG00000174606 |
| Bio databases IDs | |
| Aliases | angel homolog 2 |
| Synonyms | 2610307I21Rik, 5730410O10Rik, AI845692, angel homolog 2, CCR4D, D1Ertd396e, D1Ertd654e, KIAA0759L, RGD1305056 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGEL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein angel homolog 2 N-terminal
- mRNA 3' UTR binding
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGEL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA stabilization
- negative regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Cajal body
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- mRNA 3'-UTR binding