PABPC5 Gene Summary [Human]

This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

Details

Type
Protein Coding
Official Symbol
PABPC5
Official Name
poly(A) binding protein cytoplasmic 5 [Source:HGNC Symbol;Acc:HGNC:13629]
Ensembl ID
ENSG00000174740
Bio databases IDs NCBI: 140886 Ensembl: ENSG00000174740
Aliases poly(A) binding protein cytoplasmic 5
Synonyms C820015E17, LOC100360473, LOC302768, PABP5, poly A binding protein, cytoplasmic 5, poly(A) binding protein cytoplasmic 5, poly(A) binding protein, cytoplasmic 5
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PABPC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ELAV/HuD family splicing factor
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • protein binding
  • Occluded RNA-recognition motif

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol
  • mitochondrial matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PABPC5 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasmic stress granule
  • mitochondrial matrix
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • poly(A) RNA binding
  • poly(U) RNA binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.