PPIG Gene Summary [Human]
Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in protein peptidyl-prolyl isomerization. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPIG |
| Official Name | peptidylprolyl isomerase G [Source:HGNC Symbol;Acc:HGNC:14650] |
| Ensembl ID | ENSG00000138398 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase G, SR-related CTD-associated factor 10, cyclophilin G |
| Synonyms | AU019516, B230312B02RIK, CARS-Cyp, CLK ASSOCIATED RS CYCLOPHILIN, CYP, D5Mgi12, peptidylprolyl isomerase G, peptidyl-prolyl isomerase G (cyclophilin G), SCAF10, SRCyp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- cyclosporin A binding
- Moca domain
- enzyme
- protein binding
- cyclin-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nuclear foci
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- protein peptidyl-prolyl isomerization
- protein folding
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- cytosol
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding