DENND6A Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell-cell adhesion mediated by cadherin. Located in recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DENND6A |
| Official Name | DENN domain containing 6A [Source:HGNC Symbol;Acc:HGNC:26635] |
| Ensembl ID | ENSG00000174839 |
| Bio databases IDs | |
| Aliases | DENN domain containing 6A |
| Synonyms | AC132111.1, AFI1A, DENN domain containing 6A, FAM116A, RGD1306064 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DENND6A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DENND6A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity