DPH7 Gene Summary [Human]
Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | DPH7 |
| Official Name | diphthamide biosynthesis 7 [Source:HGNC Symbol;Acc:HGNC:25199] |
| Ensembl ID | ENSG00000148399 |
| Bio databases IDs | |
| Aliases | diphthamide biosynthesis 7 |
| Synonyms | 2810443J12Rik, C9orf112, diphthamide biosynthesis 7, diphthamine biosynethesis 7, LOC102724259, RGD1304868, RRT2, WDR85 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPH7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- WD40 repeats
- WD domain, G-beta repeat
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPH7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding