Dennd6a Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dennd6a |
| Official Name | DENN/MADD domain containing 6A [Source:MGI Symbol;Acc:MGI:2442980] |
| Ensembl ID | ENSMUSG00000040818 |
| Bio databases IDs | |
| Aliases | DENN/MADD domain containing 6A |
| Synonyms | AC132111.1, AFI1A, DENN domain containing 6A, FAM116A, RGD1306064 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dennd6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dennd6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity