DRAP1 Gene Summary [Human]
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DRAP1 |
| Official Name | DR1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:3019] |
| Ensembl ID | ENSG00000175550 |
| Bio databases IDs | |
| Aliases | DR1 associated protein 1, negative cofactor 2 alpha, DR1-associated corepressor |
| Synonyms | 2310074H19Rik, DR1 associated protein 1, NC2-alpha, NC2-α, negative cofactor 2 alpha, negative cofactor 2 α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-repressor
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- identical protein binding
- TATA-binding protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- negative cofactor 2 complex
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- DNA binding
- identical protein binding
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding