Drap1 Gene Summary [Mouse]
Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; and limb. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Drap1 |
| Official Name | Dr1 associated protein 1 (negative cofactor 2 alpha) [Source:MGI Symbol;Acc:MGI:1913806] |
| Ensembl ID | ENSMUSG00000024914 |
| Bio databases IDs | |
| Aliases | Dr1 associated protein 1 (negative cofactor 2 alpha) |
| Synonyms | 2310074H19Rik, DR1 associated protein 1, NC2-alpha, NC2-α, negative cofactor 2 alpha, negative cofactor 2 α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Drap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-repressor
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- identical protein binding
- TATA-binding protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Drap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- negative cofactor 2 complex
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- DNA binding
- identical protein binding
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding