ILF2 Gene Summary [Human]
The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ILF2 |
| Official Name | interleukin enhancer binding factor 2 [Source:HGNC Symbol;Acc:HGNC:6037] |
| Ensembl ID | ENSG00000143621 |
| Bio databases IDs | |
| Aliases | interleukin enhancer binding factor 2 |
| Synonyms | 6230405A16Rik, Ab1-143, interleukin enhancer binding factor 2, NF45, NF-AT NF45, PRO3063, TEG-267, Tex261, TEX267 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ILF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DZF domain
- transcription regulator
- double-stranded RNA binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- prostatic adenocarcinoma
- prostate cancer
- plasma cell myeloma
role in cell
- growth
- binding in
- phosphorylation in
- expression in
- transactivation in
- accumulation
- proliferation
- formation in
- transcription in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- organelle lumens
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ILF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- specific granule lumen
- membrane
- cytosol
- nucleolus
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- double-stranded RNA binding