PAAF1 Gene Summary [Human]
This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | PAAF1 |
| Official Name | proteasomal ATPase associated factor 1 [Source:HGNC Symbol;Acc:HGNC:25687] |
| Ensembl ID | ENSG00000175575 |
| Bio databases IDs | |
| Aliases | proteasomal ATPase associated factor 1 |
| Synonyms | PAAF, proteasomal ATPase associated factor 1, Rpn14, WDR71 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIID complex
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- general RNA polymerase II transcription factor activity