PSMC5 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | PSMC5 |
| Official Name | proteasome 26S subunit, ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9552] |
| Ensembl ID | ENSG00000087191 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 5 |
| Synonyms | 26s Protease Regulatory Subunit 8, LOC81827, mSUG1, p45, p45/SUG, protease (prosome, macropain) 26S subunit, ATPase 5, proteasome 26S subunit, ATPase 5, PRS8, RPT6, Rtp6, S8, SUG-1, TBP10, TRIP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Proteasomal ATPase OB C-terminal domain
- transcription regulator
- G-protein-coupled receptor binding
- transcription factor binding
- isomerase
- leucine zipper domain
- coiled-coil domain
- enzyme
- protein binding
- receptor binding
- AAA domain (Cdc48 subfamily)
- AAA+ lid domain
- ATPase
- TATA-binding protein binding
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- Lyn binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the PSMC5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- growth
- cell death
- quantity
- assembly
- binding in
- assembly in
- aggregation in
- cell viability
- dipeptide repeat protein sensitivity
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular space
- postsynaptic region
- Plasma Membrane
- cytosol
- nucleoplasm
- clastosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of programmed cell death
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle, base subcomplex
- cytoplasm
- blood microparticle
- membrane
- cytosol
- cytoplasmic vesicle
- proteasome accessory complex
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- thyrotropin-releasing hormone receptor binding
- transcription factor binding