PTPN2 Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Details
| Type | Retained Intron |
| Official Symbol | PTPN2 |
| Official Name | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] |
| Ensembl ID | ENSG00000175354 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase non-receptor type 2 |
| Synonyms | protein tyrosine phosphatase non-receptor type 2, protein tyrosine phosphatase, non-receptor type 2, PTN2, PTPase, Ptps, PTPT, Tc45, TCELLPTP, T CELL PTPASE, TC-PTP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-membrane spanning protein tyrosine phosphatase
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- transcription factor binding
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- DNA binding
- syntaxin binding
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- receptor tyrosine kinase binding
- integrin binding
- phosphatase
Pathways
Biological processes and signaling networks where the PTPN2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- dermatitis
- psoriasis
- rheumatoid arthritis
- inflammatory bowel disease
- Crohn disease
- prostate cancer
- diarrhea
- ulcerative colitis
- systemic lupus erythematosus
role in cell
- expression in
- activation in
- proliferation
- phosphorylation in
- growth
- generation
- survival
- differentiation
- growth in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- negative regulation of tyrosine phosphorylation of STAT protein
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of gluconeogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of macrophage differentiation
- negative regulation of interleukin-6-mediated signaling pathway
- peptidyl-tyrosine dephosphorylation
- B cell differentiation
- negative regulation of inflammatory response
- negative regulation of type I interferon-mediated signaling pathway
- insulin receptor recycling
- regulation of interferon-gamma-mediated signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of JAK-STAT cascade
- negative regulation of interferon-gamma-mediated signaling pathway
- T cell differentiation
- negative regulation of T cell receptor signaling pathway
- erythrocyte differentiation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- glucose homeostasis
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of lipid storage
- negative regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- endosome lumen
- cytosol
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- syntaxin binding
- integrin binding
- receptor tyrosine kinase binding