C8G Gene Summary [Human]
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
Details
| Type | Retained Intron |
| Official Symbol | C8G |
| Official Name | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] |
| Ensembl ID | ENSG00000176919 |
| Bio databases IDs | |
| Aliases | complement C8 gamma chain |
| Synonyms | 1700013L23RIK, C8C, C8 gamma subunit, C8 γ subunit, complement C8 gamma chain, complement C8 γ chain, complement component 8, gamma polypeptide, complement component 8, γ polypeptide |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C8G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the C8G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C8G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, alternative pathway
- complement activation, classical pathway
- killing of cells of other organism
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- complement binding
- retinol binding