icon_0328_cc_gen_hmr_bacteria-s

Complement System

The complement system is a cascade of enzyme activations that bridge the innate and accquired immune systems. Biological effects of the complement system include opsonization, lysis of foreign cells, clearance of immune complexes and apoptotic cells, activation of inflammation and augmenting the antibody response....

Complement System

Pathway Summary

The complement system is a cascade of enzyme activations that bridge the innate and accquired immune systems. Biological effects of the complement system include opsonization, lysis of foreign cells, clearance of immune complexes and apoptotic cells, activation of inflammation and augmenting the antibody response.The complement system has three pathways based on initiation of the complement cascade: classical pathway, alternate pathway and lectin pathway. The classical pathway is triggered by the binding of C1 (a complex of complement associated proteins) to the antigen-antibody (Ag-Ab) complex. The lectin pathway is independent of Ag-Ab complex and is initiated by MBL (mannose binding lectin), a serum protein, binding to mannose groups on bacterial cell walls. The alternate pathway is activated by C3, a complement protein, binding to components of microbial cell surfaces.The three activation pathways converge into a final common pathway when C3 convertase cleaves C3 into C3a and C3b where C3b is directly linked to opsonization and also goes on to form part of the complex that cleaves C5 into C5a and C5b. C5b with C6, C7, C8, and C9 form (C5b6789) the membrane attack complex, also known as MAC, which is inserted into the cell membrane and initiates cells lysis.

Products related to Complement System

Explore products related to Complement System
GeneGlobe ID: UPHS-053Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human T-Cell & B-Cell Activation
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-052Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Innate & Adaptive Immune Responses
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-052Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Innate & Adaptive Immune Responses
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-053Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human T-Cell & B-Cell Activation
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-053Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human T-Cell & B-Cell Activation
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-052Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Innate & Adaptive Immune Responses
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.