C8g Gene Summary [Mouse]
This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | C8g |
| Official Name | complement component 8, gamma polypeptide [Source:MGI Symbol;Acc:MGI:88237] |
| Ensembl ID | ENSMUSG00000015083 |
| Bio databases IDs | |
| Aliases | complement component 8, gamma polypeptide |
| Synonyms | 1700013L23RIK, C8C, C8 gamma subunit, C8 γ subunit, complement C8 gamma chain, complement C8 γ chain, complement component 8, gamma polypeptide, complement component 8, γ polypeptide |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C8g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the C8g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C8g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, alternative pathway
- complement activation, classical pathway
- killing of cells of other organism
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- complement binding
- retinol binding