S1PR2 Gene Summary [Human]
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | S1PR2 |
| Official Name | sphingosine-1-phosphate receptor 2 [Source:HGNC Symbol;Acc:HGNC:3169] |
| Ensembl ID | ENSG00000267534 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate receptor 2 |
| Synonyms | 1100001A16Rik, AGR16, DFNB68, EDG-5, Gpcr13, GPCR18, H218, LPB2, S1P2, snGPCR18, sphingosine-1-phosphate receptor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S1PR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- bioactive lipid receptor
- Cholecystokinin A receptor, N-terminal
- lipid binding
- integrin binding
- G-protein-coupled receptor binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the S1PR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- Ceramide Signaling
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- Phagosome Formation
- Sphingosine-1-phosphate Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- epithelial cancer
- cancer
- bleeding
- insulin resistance
- ulcerative colitis
- atopic dermatitis
- hepatic fibrosis
- atrial fibrillation
role in cell
- expression in
- production in
- chemotaxis
- apoptosis
- cell viability
- activation in
- proliferation
- migration
- quantity
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S1PR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- G-protein coupled receptor signaling pathway
- positive regulation of cell proliferation
- regulation of metabolic process
- positive regulation of peptidyl-threonine phosphorylation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- negative regulation of excitatory postsynaptic membrane potential
- actin cytoskeleton organization
- sphingosine-1-phosphate signaling pathway
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate receptor activity
- G-protein coupled receptor activity
- G-protein coupled receptor binding
- G-protein coupled peptide receptor activity
- protein binding
- lipid binding
- integrin binding