CETN1 Gene Summary [Human]
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | CETN1 |
| Official Name | centrin 1 [Source:HGNC Symbol;Acc:HGNC:1866] |
| Ensembl ID | ENSG00000177143 |
| Bio databases IDs | |
| Aliases | centrin 1 |
| Synonyms | caltractin, CEN1, centrin 1, CETN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CETN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- EF-hand, calcium binding motif
- EF-hand domain
- binding protein
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- EFh
- enzyme
- protein binding
- EFh_MICU
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- centrosome
- centriole
- microtubule organizing centers
- cytosol
- connecting cilia
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CETN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cellular response to heat
- centriole replication
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- nucleus
- centrosome
- centriole
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heterotrimeric G-protein binding
- G-protein beta/gamma-subunit complex binding
- microtubule binding