Cetn1 Gene Summary [Mouse]
Enables G-protein beta/gamma-subunit complex binding activity; heterotrimeric G-protein binding activity; and microtubule binding activity. Acts upstream of or within cellular response to heat. Located in centrosome and photoreceptor connecting cilium. Is expressed in embryo; inner cell mass; and photoreceptor layer. Orthologous to human CETN1 (centrin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cetn1 |
| Official Name | centrin 1 [Source:MGI Symbol;Acc:MGI:1347086] |
| Ensembl ID | ENSMUSG00000050996 |
| Bio databases IDs | |
| Aliases | centrin 1 |
| Synonyms | caltractin, CEN1, centrin 1, CETN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cetn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- EF-hand, calcium binding motif
- EF-hand domain
- binding protein
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- EFh
- enzyme
- protein binding
- EFh_MICU
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- centrosome
- centriole
- microtubule organizing centers
- cytosol
- connecting cilia
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cetn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cellular response to heat
- centriole replication
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- nucleus
- centrosome
- centriole
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heterotrimeric G-protein binding
- G-protein beta/gamma-subunit complex binding
- microtubule binding