DHFR2 Gene Summary [Human]
Enables dihydrofolate reductase activity and mRNA binding activity. Involved in tetrahydrofolate metabolic process and thymidine biosynthetic process. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | DHFR2 |
| Official Name | dihydrofolate reductase 2 [Source:HGNC Symbol;Acc:HGNC:27309] |
| Ensembl ID | ENSG00000178700 |
| Bio databases IDs | |
| Aliases | dihydrofolate reductase 2 |
| Synonyms | DHFRL1, DHFRP4, dihydrofolate reductase 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHFR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dihydrofolate reductase
- mRNA binding
- DHFR
- CH-NH group:NAD or NADP oxidoreductase
- enzyme
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHFR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dihydrofolate metabolic process
- thymidine biosynthetic process
- folic acid metabolic process
- tetrahydrofolate metabolic process
- tetrahydrofolate biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADP binding
- folate reductase activity
- mRNA binding
- dihydrofolate reductase activity