BTF3 Gene Summary [Human]

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
BTF3
Official Name
basic transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:1125]
Ensembl ID
ENSG00000145741
Bio databases IDs NCBI: 689 Ensembl: ENSG00000145741
Aliases basic transcription factor 3
Synonyms 1700054E11RIK, basic transcription factor 3, BETA-NAC, NACB, β-NAC
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • protein binding
  • NAC domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • nonalcoholic fatty liver disease
  • pancreatic epithelial cancer
  • pancreatic ductal adenocarcinoma
  • ductal pancreatic cancer
regulated by
regulates
role in cell
  • apoptosis
  • phosphorylation in
  • pyroptosis
  • replication in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human BTF3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • in utero embryonic development
  • protein transport

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nascent polypeptide-associated complex
  • cytoplasm
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.