GPC5 Gene Summary [Human]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPC5 |
| Official Name | glypican 5 [Source:HGNC Symbol;Acc:HGNC:4453] |
| Ensembl ID | ENSG00000179399 |
| Bio databases IDs | |
| Aliases | glypican 5, glypican proteoglycan 5 |
| Synonyms | A230034F01Rik, glypican 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- ectodomain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- epithelial neoplasia
- Alzheimer disease
- COVID-19
- edema
- insomnia
- arthropathy
- breast carcinoma
- nephrosis
- rheumatoid arthritis
role in cell
- proliferation
- growth
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
- Extracellular Space
- cellular membrane
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of canonical Wnt receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- lysosomal lumen
- Golgi lumen
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding