POU2F1
POU2F1 Gene Summary
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | POU2F1 |
| Official Name | POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9212] |
| Ensembl ID | ENSG00000143190 |
| Bio databases IDs | |
| Aliases | POU class 2 homeobox 1 |
| Synonyms | 2810482H01Rik,LOC100503933,NF-A1,OCT1,oct-1B,Oct1Z,OTF1,POU class 2 homeobox 1,POU domain, class 2, transcription factor 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- nucleic acid binding
- chromatin binding
- linker domain
- protein binding
- receptor binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- POU specific domain
- homeodomain
- amino terminal activation domain
- POU domain, class 2, transcription factor 1 C-terminal
Pathways
Biological processes and signaling networks where the POU2F1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PARP1
- ESR1
- H3C3
- ATP5F1B
- Ptp
- RXRA
- STAT5A
- POU2AF1
- NFKB1
- CREB
disease
- anemia
- coronary artery disease
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
regulated by
- tetradecanoylphorbol acetate
- ethanol
- lipopolysaccharide
- LDL
- troglitazone
- TNF
- DCLK1
- thyroid hormone
- TP53
- ESR1
regulates
- reactive oxygen species
- SOD1
- IL6
- NFKB1
- TLR4
- CYP2C9
- IL2
- reporter gene
- ICAM1
- BRCA1
role in cell
- expression in
- quantity
- activation in
- proliferation
- survival
- assembly
- pluripotency
- silencing in
- binding in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- insoluble fractions
- intracellular membrane-bounded organelle
- Cytoplasm
- intranuclear region
- Endoplasmic Reticulum
- perinucleolar compartments
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the POU2F1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity