BOD1 Gene Summary [Human]
Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BOD1 |
| Official Name | biorientation of chromosomes in cell division 1 [Source:HGNC Symbol;Acc:HGNC:25114] |
| Ensembl ID | ENSG00000145919 |
| Bio databases IDs | |
| Aliases | biorientation of chromosomes in cell division 1, biorientation defective 1 |
| Synonyms | 2310022M17Rik, biorientation of chromosomes in cell division 1, BOD2.1, Bodq1, FAM44B, RGD1305622 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BOD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- COMPASS (Complex proteins associated with Set1p) component shg1
- protein phosphatase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- chromosome
- nucleoplasm
- spindle pole
- spindle fibers
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BOD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of phosphoprotein phosphatase activity
- mitotic sister chromatid cohesion, centromeric
- mitotic metaphase plate congression
- protein localization to chromosome, centromeric region
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- spindle microtubule
- centrosome
- cytoplasm
- spindle pole
- condensed chromosome outer kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein phosphatase 2A binding