HTR1D Gene Summary [Human]
Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HTR1D |
| Official Name | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] |
| Ensembl ID | ENSG00000179546 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 1D |
| Synonyms | 5-HT-1D, 5HT1D receptor, 5HTR1D, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine (serotonin) receptor 1D, Gpcr14, HT1DA, HTR1DA, HTR1DB, HTRL, RDC4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 5-HT1 receptor
- serotonin receptor
- serotonin binding
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR1D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HTR1B
- donitriptan
- frovatriptan
- naratriptan
- zolmitriptan
- almotriptan
- vortioxetine
- fenfluramine
- ergotamine
- rizatriptan
disease
- liver cancer
- Huntington disease
- non-insulin-dependent diabetes mellitus
- obesity
- insulin resistance
- schizophrenia
- headache
- migraines
- metabolic syndrome X
- acute migraine
regulates
- TGM2
- Gαi/o
role in cell
- apoptosis
- proliferation
- migration
- transmission
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of behavior
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- regulation of locomotion
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- intestine smooth muscle contraction
- synaptic transmission
- vasoconstriction
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter receptor activity
- serotonin receptor activity