TPPP2 Gene Summary [Human]
Enables tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TPPP2 |
| Official Name | tubulin polymerization promoting protein family member 2 [Source:HGNC Symbol;Acc:HGNC:19293] |
| Ensembl ID | ENSG00000179636 |
| Bio databases IDs | |
| Aliases | tubulin polymerization promoting protein family member 2 |
| Synonyms | C14orf8, CT152, Foxo3, Gm1790, Gm77, P18, p25beta, RGD1566185, tubulin polymerization-promoting protein family member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPPP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- p25-alpha
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPPP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- spermatogenesis
- positive regulation of protein polymerization
- cell differentiation
- microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- cytosol
- sperm flagellum
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding