DEFB124 Gene Summary [Human]
Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. The encoded protein may serve to enhance innate immunity in the prostate. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | DEFB124 |
| Official Name | defensin beta 124 [Source:HGNC Symbol;Acc:HGNC:18104] |
| Ensembl ID | ENSG00000180383 |
| Bio databases IDs | |
| Aliases | defensin beta 124, defensin, beta 24 |
| Synonyms | BD-25, DEFB-24, Defb25, defensin beta 124, defensin beta 25, defensin β 124, defensin β 25, mBD-25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DEFB124 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
Pathways
Biological processes and signaling networks where the DEFB124 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DEFB124 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of monocyte chemotaxis
- innate immune response
- cellular response to peptidoglycan
- I-kappaB kinase/NF-kappaB cascade
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding