Defb25 Gene Summary [Rat]
Predicted to be involved in several processes, including cellular response to peptidoglycan; positive regulation of cytokine production; and positive regulation of monocyte chemotaxis. Predicted to be located in extracellular region. Orthologous to human DEFB124 (defensin beta 124). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb25 |
| Official Name | defensin beta 25 [Source:RGD Symbol;Acc:1564765] |
| Ensembl ID | ENSRNOG00000036895 |
| Bio databases IDs | |
| Aliases | defensin beta 25 |
| Synonyms | BD-25, DEFB-24, Defb25, defensin beta 124, defensin beta 25, defensin β 124, defensin β 25, mBD-25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Defb25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
Pathways
Biological processes and signaling networks where the Defb25 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Defb25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of monocyte chemotaxis
- innate immune response
- cellular response to peptidoglycan
- I-kappaB kinase/NF-kappaB cascade
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding