ZSCAN4 Gene Summary [Human]
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
Details
| Type | Processed Transcript |
| Official Symbol | ZSCAN4 |
| Official Name | zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709] |
| Ensembl ID | ENSG00000180532 |
| Bio databases IDs | |
| Aliases | zinc finger and SCAN domain containing 4 |
| Synonyms | zinc finger and SCAN domain containing 4, ZNF494 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZSCAN4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- leucine rich region
- transcription regulator
- double-stranded DNA binding
- Zinc-finger double domain
- SCAN domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZSCAN4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere maintenance via telomere lengthening
- negative regulation of mitotic recombination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity