TNFSF14 Gene Summary [Human]
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFSF14 |
| Official Name | TNF superfamily member 14 [Source:HGNC Symbol;Acc:HGNC:11930] |
| Ensembl ID | ENSG00000125735 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 14 |
| Synonyms | CD258, HVEM-L, LIGHT, LTg, Ly113, TNF superfamily member 14, TNLG1D, tumor necrosis factor (ligand) superfamily, member 14, tumour necrosis factor (ligand) superfamily, member 14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFSF14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- cytoplasmic domain
- TNF
- caspase inhibitor activity
- transmembrane domain
- protein binding
- receptor binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the TNFSF14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- splenomegaly
- pulmonary fibrosis
- multiple sclerosis
- hepatitis
- lymphadenopathy
- experimental autoimmune encephalomyelitis
- diabetic nephropathy
- systemic lupus erythematosus
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- proliferation
- production in
- growth
- cell death
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFSF14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- immune response
- T cell chemotaxis
- T cell costimulation
- signal transduction
- apoptotic process
- T cell proliferation
- positive regulation of T cell chemotaxis
- T cell activation
- positive regulation of myoblast differentiation
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- receptor binding