PARD6B Gene Summary [Human]
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PARD6B |
| Official Name | par-6 family cell polarity regulator beta [Source:HGNC Symbol;Acc:HGNC:16245] |
| Ensembl ID | ENSG00000124171 |
| Bio databases IDs | |
| Aliases | par-6 family cell polarity regulator beta |
| Synonyms | AV025615, PAR6B, par-6 family cell polarity regulator beta, par-6 family cell polarity regulator β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARD6B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ binding motif
- PDZ domain
- PB1
Pathways
Biological processes and signaling networks where the PARD6B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- migration
- formation
- formation in
- development
- reassembly
- assembly
- retention in
- misorientation in
- misorientation
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- apical compartment
- cell cortex
- Nucleus
- cytosol
- apical cell surfaces
- membrane ruffles
- apical membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARD6B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of cellular localization
- centrosome cycle
- cell-cell junction assembly
- macromolecular complex assembly
- establishment or maintenance of epithelial cell apical/basal polarity
- axonogenesis
- establishment or maintenance of cell polarity
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- occluding junction
- extracellular vesicular exosome
- cell cortex
- cytosol
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding