SLC36A4 Gene Summary [Human]
SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC36A4 |
| Official Name | solute carrier family 36 member 4 [Source:HGNC Symbol;Acc:HGNC:19660] |
| Ensembl ID | ENSG00000180773 |
| Bio databases IDs | |
| Aliases | solute carrier family 36 member 4 |
| Synonyms | 6330573I15Rik, PAT4, solute carrier family 36 member 4, solute carrier family 36 (proton/amino acid symporter), member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC36A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline transporter
- alanine transporter
- tryptophan transporter
- Solute carrier families 5 and 6-like; solute binding domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC36A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-alanine transport
- tryptophan transport
- proline transport
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- vacuolar membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- L-tryptophan transmembrane transporter activity
- symporter activity
- L-proline transmembrane transporter activity
- L-alanine transmembrane transporter activity