P2RY13 Gene Summary [Human]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | P2RY13 |
| Official Name | purinergic receptor P2Y13 [Source:HGNC Symbol;Acc:HGNC:4537] |
| Ensembl ID | ENSG00000181631 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y13 |
| Synonyms | 2010001L06Rik, FKSG77, GPCR1, GPR86, GPR94, P2Y13, P2Y purinoceptor 13, P2yr13, purinergic receptor P2Y13, purinergic receptor P2Y, G-protein coupled 13, SP174 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- purinergic G-protein coupled nucleotide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2RY13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- Alzheimer disease
- organismal death
- streptozotocin induced type1 diabetes
- androgenic alopecia
- ulcerative colitis
- lung adenocarcinoma
- lung adenocarcinoma formation
- idiopathic pulmonary fibrosis
- colorectal cancer
regulated by
- adenosine triphosphate
- 2-methylthio-ADP
- ADP
- Immunoglobulin
- pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
- cigarette smoke
- inosine diphosphate
- losartan potassium
- 2-methylthio-ATP
- diadenosine triphosphate
role in cell
- inhibition in
- expression in
- phosphorylation in
- quantity
- function
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cellular response to organic cyclic compound
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein coupled purinergic nucleotide receptor activity