WDTC1 Gene Summary [Human]
Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WDTC1 |
| Official Name | WD and tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:29175] |
| Ensembl ID | ENSG00000142784 |
| Bio databases IDs | |
| Aliases | WD and tetratricopeptide repeats 1, adipose homolog (Drosophila), DDB1 and CUL4 associated factor 9 |
| Synonyms | adipose, ADP, DCAF9, Gm695, WD and tetratricopeptide repeats 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDTC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- TPR repeat
- WD40 repeats
- Tetratricopeptide repeats
- enzyme inhibitor activity
- WD domain, G-beta repeat
- histone deacetylase binding
- protein binding
- tetratricopeptide repeat
- Anaphase-promoting complex, cyclosome, subunit 3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDTC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular chemical homeostasis
- negative regulation of fatty acid biosynthetic process
- cellular response to insulin stimulus
- multicellular organism growth
- in utero embryonic development
- regulation of cell size
- glucose metabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- histone binding
- enzyme inhibitor activity