IZUMO1 Gene Summary [Human]
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | IZUMO1 |
| Official Name | izumo sperm-egg fusion 1 [Source:HGNC Symbol;Acc:HGNC:28539] |
| Ensembl ID | ENSG00000182264 |
| Bio databases IDs | |
| Aliases | izumo sperm-egg fusion 1, oocyte binding/fusion factor |
| Synonyms | 1700058F15Rik, IZUMO, izumo sperm-egg fusion 1, izumo sperm-oocyte fusion 1, OBF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IZUMO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- Izumo-like Immunoglobulin domain
- protein homodimerization
- receptor agonist activity
- protein binding
- receptor binding
- identical protein binding
- Izumo sperm-egg fusion, Ig domain-associated
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- endoplasmic reticulum membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IZUMO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm-egg recognition
- cell adhesion
- fusion of sperm to egg plasma membrane
- heterotypic cell-cell adhesion
- single fertilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- acrosomal membrane
- acrosomal vesicle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein binding involved in heterotypic cell-cell adhesion
- receptor binding