PTPRF Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PTPRF |
| Official Name | protein tyrosine phosphatase receptor type F [Source:HGNC Symbol;Acc:HGNC:9670] |
| Ensembl ID | ENSG00000142949 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase receptor type F |
| Synonyms | BNAH2, LAR, Lar ptp2b, LARS, Leukocyte Antigen Related Protein Phosphatase, protein tyrosine phosphatase receptor type F, protein tyrosine phosphatase, receptor type, F, Receptor-type tyrosine-protein phosphatase F precursor, RPTP-LAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPRF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- protein-tyrosine-phoshatase
- cell adhesion molecule binding
- wedge domain
- Protein tyrosine phosphatase, catalytic domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- cytoplasmic domain
- receptor tyrosine kinase binding
- protein phosphatase
- Immunoglobulin like
- phosphatase
- intracellular domain
- extracellular domain
- catalytic domain
- ectodomain
- immunoglobulin domain
- Immunoglobulin I-set domain
- Purple acid Phosphatase, N-terminal domain
- protein binding
- phosphatase domain
- phosphate binding
- glycosaminoglycan binding
- PTPase domain
- FNIII-like repeat
- binding protein
- FN3
- transmembrane receptor protein tyrosine phosphatase
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the PTPRF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atresia
- colloid breast carcinoma
- mucinous breast cancer
- schizophrenia
- cannabis dependence
- hypoplasia
- colon cancer
- dilation of ureter
- major depression
role in cell
- proliferation
- formation
- apoptosis
- cell death
- quantity
- binding
- growth
- migration
- phosphorylation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- focal adhesions
- endosomes
- Golgi Apparatus
- intercellular junctions
- desmosomes
- cell-cell contacts
- synaptic membrane
- growth cone
- neurites
- synaptosomes
- synapse
- ruffled borders
- anchoring junction
- perikaryon
- dendrites
- excitatory synapses
- cell-cell adherens junctions
- plasma
- axon cylinder
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPRF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of receptor binding
- transmembrane receptor protein tyrosine phosphatase signaling pathway
- regulation of axon regeneration
- neuron projection regeneration
- cell adhesion
- peptidyl-tyrosine dephosphorylation
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- neuronal cell body
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein tyrosine phosphatase activity
- chondroitin sulfate proteoglycan binding
- cell adhesion molecule binding
- heparin binding
- transmembrane receptor protein tyrosine phosphatase activity