Izumo1 Gene Summary [Mouse]
Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and receptor ligand activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization and syncytium formation by plasma membrane fusion. Acts upstream of or within sperm-egg recognition. Located in acrosomal membrane and endoplasmic reticulum membrane. Part of protein complex involved in cell-cell adhesion. Is active in plasma membrane. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Izumo1 |
| Official Name | izumo sperm-egg fusion 1 [Source:MGI Symbol;Acc:MGI:1920706] |
| Ensembl ID | ENSMUSG00000064158 |
| Bio databases IDs | |
| Aliases | izumo sperm-egg fusion 1 |
| Synonyms | 1700058F15Rik, IZUMO, izumo sperm-egg fusion 1, izumo sperm-oocyte fusion 1, OBF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Izumo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- Izumo-like Immunoglobulin domain
- protein homodimerization
- receptor agonist activity
- protein binding
- receptor binding
- identical protein binding
- Izumo sperm-egg fusion, Ig domain-associated
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- endoplasmic reticulum membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Izumo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm-egg recognition
- cell adhesion
- fusion of sperm to egg plasma membrane
- heterotypic cell-cell adhesion
- single fertilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- acrosomal membrane
- acrosomal vesicle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein binding involved in heterotypic cell-cell adhesion
- receptor binding